Obtenção de fibras de blendas zeína/PNIPAAm por eletrofiação em solução
Studies to biomaterials seek alternatives that can enhance the quality of life man, through more effective treatments. Zein is biocompatible, biodegradable and it is obtained from a renewable source. Poly(N-sopropylacrylamide) (PNNIPAm) exhibits thermosensitivity and biocompatibility property, but i...
| Autor principal: | Torres, Sandro Junior Vessoni |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2020
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/12265 |
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| Resumo: |
Studies to biomaterials seek alternatives that can enhance the quality of life man, through more effective treatments. Zein is biocompatible, biodegradable and it is obtained from a renewable source. Poly(N-sopropylacrylamide) (PNNIPAm) exhibits thermosensitivity and biocompatibility property, but it is not biodegradable. The combination of zein and PNNIPAm forming a polymer blend is a very interesting strategy that can enable the production of a biomaterial with better properties than those of the pure polymers. The processing of such blends by electrospinning shows promise in obtaining biocompatible fibers, being a simple and efficient method, which can result in fibers with different morphologies in accordance with previously set parameters. In this work, zein/PNIPAAm blends fiber was obtained by electrospinning solution. DSC and TGA analyzed the thermal behavior of the fiber obtained. The morphology by optical microscopy and scanning electron microscopy, and the diameter of the fibers and the process yield was evaluated based on the variation of process parameters and concentration, by fractional planning. In aqueous-alcohol solution, electrospun zein/PNIPAAm fibers showed the formation of the beads, but the variation of process parameters not removed the beads. In chloroform/N,N-dimethylformamide mixture and using 22 kV as electric field, the electrospun fibers showed a uniform morphology without beads. The factorial design technique was employed to evaluate the influence of solution concentrations, distance between needle tip and collector, applied voltage, solution flow on the fiber diameters and the yield of fibers formed. The results showed that the concentration and the flow parameters influence more significantly in reducing the fiber diameters. For the yield of fibers, the solution concentration and flow had more influence. The thermal analysis it was found a single glass transition temperature for the two polymers in the form of blends, and show that the degradation onset temperature undergoes no large variation in function of the ratio of PNIPAAm. Thus, it was observed that the tension exerted no significant effect on the results and that the fibers obtained do not suffer large variations in thermal behavior as a function of the percentage of PNIPAAm. |
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