Proposta de obtenção de metalofármacos de paládio (II) utilizando tiossemicarbazonas derivadas do limoneno
The study and development of metal-drugs in the medical area aim to propose the synthesis of new complexes that may be amenable to the treatment of some pathologies and, at the same time, present fewer side effects to the patients. This study involves several areas of knowledge such as Inorganic and...
| Autor principal: | Beltrame, Ariane Carolina Ferreira |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2020
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/12358 |
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| Resumo: |
The study and development of metal-drugs in the medical area aim to propose the synthesis of new complexes that may be amenable to the treatment of some pathologies and, at the same time, present fewer side effects to the patients. This study involves several areas of knowledge such as Inorganic and Organic Chemistry, Immunology, Biochemistry and others. The union of these areas is responsible for the development and evolution of some compounds and their efficiency as drugs in different treatments in several diseases. The aim of the present study was to synthesize and study palladium(II) complexes using the ligands 3 and 4-nitrobenzaldehyde-thiosemicarbazone, both derived from limonene. The ligands were characterized by 13C and 1H NMR and IV, while infrared (IV), thermogravimetric (TGA) and X-rays dust characterized the complexes. The data obtained from IV allowed to infer that the complexes presented monomeric structures; the Cl- halide and the pseudohalide SCN- are terminately coordinated, the thiocyanate being via sulfur atom. Limonene-derived binders were chelatingly coordinated to the palladium (II) metal center via the imino and thiocarbonyl carbon of thiosemicarbazone. From the results of thermogravimetry it was possible to establish a decreasing order of thermal stability, considering the initial temperature of decomposition for complexes of the same series. |
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