Síntese de biomateriais à base de Ti6Al4V/TiO2NT para liberação de benzocaína
In the present study, the effect of anodizing time on the properties of titanium dioxide nanotubular coatings on Ti6Al4V implants was investigated, such as morphology, wettability, bioactivity, corrosion resistance and its use as a platform for benzocaine release. The surface modification was carrie...
| Autor principal: | Silva, Bruna Lemes da |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2022
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/27836 |
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| Resumo: |
In the present study, the effect of anodizing time on the properties of titanium dioxide nanotubular coatings on Ti6Al4V implants was investigated, such as morphology, wettability, bioactivity, corrosion resistance and its use as a platform for benzocaine release. The surface modification was carried out through the growth of nanotubes developed in electrolytic medium based on SBF, ethylene glycol and ammonium fluoride, varying the synthesis time in 10 and 30 min. The samples were characterized by SEM, contact angle and XRD. Corrosion as well as release tests of the model drug are carried out in order to investigate the drug/biomaterial/release medium interaction potential. The results indicate that it is possible to synthesize highly organized nanotubes with 10 min of anodizing, and the self-organization and wettability of the materials are inversely proportional to the increase in the anodizing time. The bioactivity test showed that all films can promote a similar deposition of fluorapatite within 30 days. Corrosion tests indicate that the sample with 30 min showed a protective layer and less susceptible to corrosion compared to untreated metal. This condition also showed an increase in the amount of drug mass released as a function of time (12 hours) due to the lower wettability, larger diameter of nanotubes and possible increase in the length of the nanotubes. Thus, it is possible to obtain highly organized, biocompatible, corrosion resistant coatings with potential for use as drug release matrices, relevant results for the development of technologies applicable to the metallic implant industry. |
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