A competição entre as reações de Clarke-Eschweiler e Pictet-Spengler em fluxo sequencial de plugues
Herein is described the syntheses of 2-phenylethylamine and homoveratrylamine. The former was used to study the competition between the Clarke-Eschweiler and Pictet-Spengler reactions using segmented plug flow. A flow chemistry system was built around an arduino compatible microcontroller. Syringe p...
| Autor principal: | Spano, Michael Brandon Schroder |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2020
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/9139 |
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| Resumo: |
Herein is described the syntheses of 2-phenylethylamine and homoveratrylamine. The former was used to study the competition between the Clarke-Eschweiler and Pictet-Spengler reactions using segmented plug flow. A flow chemistry system was built around an arduino compatible microcontroller. Syringe pumps were constructed using a 3D printer. The following conditions were tested using sequential plug flow: temperature of 70 °C and 100 °C; and reaction times of 1 min, 5 min and 10 min. The main product observed from sequential plug flow was N,N-dimethyl-2-phenylethylamine when the temperature was 100 °C and reaction time was 1 minute. Pictet-Spengler type products were not observed for the reaction with 2-phenylethylamine as was expected. |
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