Avaliação preliminar da degradação de comprimidos de ibuprofeno através do processo UV/H2O2
Worldwide population usually ingest drugs by indication of neighbors and family members, resulting in indiscriminate consumption. Due to lack of information, there are doubts as the proper way to disposal of it, and most people believe that it is the common trash. Also due to the problem of infrastr...
| Autor principal: | Biasi, Débora |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2020
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/9183 |
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| Resumo: |
Worldwide population usually ingest drugs by indication of neighbors and family members, resulting in indiscriminate consumption. Due to lack of information, there are doubts as the proper way to disposal of it, and most people believe that it is the common trash. Also due to the problem of infrastructure in Brazil, many pharmaceuticals are introduced directly into the environment. The current Brazilian legislation classifies it as Health services waste, considered as hazardous (Class B) and the recommended treatment consists of incineration or disposal in landfill when collected properly. Alternative treatments have been studied, such as oxidative processes, usually used for degradation of organic matter. The objective of this work was the assessment of the degradation of ibuprofen tablets expired in solution by UV/H2O2 process. For this purpose, were used two separate reactors, the first using a low pressure mercury lamp with 28W and an internal volume of 1L and the latter with a high pressure mercury lamp with 125W in a 500 ml reactor, both using sample recirculation. The solutions were prepared to a final concentration of 1,2 g L-1 ibuprofen with pH 8, and for the second reactor one of the samples passed through an acid hydrolysis. The reaction was monitored using highperformance liquid chromatography with diode array detector (HPLC-DAD) and also: peroxide concentration, UV-Vis, COD, turbidity and antimicrobial activity (Bacillus subtilis). The reactor with low pressure lamp took 450 minutes to consumption of 80% of the peroxide with 50% removal of COD and turbidity of 61,5%. As for the reactor with high pressure lamp 300 minutes were required to consume the same amount of oxidant, but with less reduction in COD and turbidity (26 and 40%, respectively). For the sample with hydrolysis, it was observed a high deposition of precipitate on the lamp bulb causing lower consumption of peroxide (50%) and therefore less reduction of COD (25%). The antimicrobial activity was high before the treatment and after it was lower but similar for all post-treatment samples without changing inhibition with dilution. The results of this preliminary analysis is that the process is highly influenced by the excipients found in the tablets. |
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