Cristalização e identificação polimórfica do fármaco Cimetidina
Polymorphism is the tendency of a substance to crystallize in different forms. These may have distinct properties, such as melting point, X-ray diffraction, molecular spectrum, stability, solubility, as well as loss of therapeutic efficacy and bioequivalence of the drug. In this context, this work w...
| Autor principal: | Santos, Gabriel da Costa |
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| Formato: | Trabalho de Conclusão de Curso (Graduação) |
| Idioma: | Português |
| Publicado em: |
Universidade Tecnológica Federal do Paraná
2020
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| Assuntos: | |
| Acesso em linha: |
http://repositorio.utfpr.edu.br/jspui/handle/1/13259 |
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| Resumo: |
Polymorphism is the tendency of a substance to crystallize in different forms. These may have distinct properties, such as melting point, X-ray diffraction, molecular spectrum, stability, solubility, as well as loss of therapeutic efficacy and bioequivalence of the drug. In this context, this work will include techniques of crystallization and polymorphic identification, besides draw a thermal profile of the drug Cimetidine, that is used in conditions in which the inhibition of gastric secretion can be beneficial, as in gastric or duodenal ulcers. For the recrystallization technique, different solvents and temperature conditions were used for obtaining and storing the crystals. The analyzes of these were performed with the aid of infrared spectroscopy and tracing a thermal profile for the polymorphs obtained, identifying and quantifying the events endothermic or exothermic processes through the differential exploratory calorimetry (DSC). Moreover, was performing a morphological study of crystals, obtained by optical microscopy in order to gain polymorphic forms of the drug Cimetidine. The results and characterizations performed through infrared spectroscopy, indicated displacements in the bands of these regions of 600 to 1400 cm-1 and 2178 to 2166 cm -1, being this a characteristic of the nitrile group (C≡N), identifying the presence of two or more forms polymorphic. Meanwhile, with the optical microscopy the different crystalline forms were observed in all the solvents used under the two temperature conditions submitted, allowing to consider the occurrence of the described phenomena. However, as these analyzes described do not confirm the presence of the polymorphism a thermal study was used for the reliability of the same. In other words, with the analyzes performed using the DSC, noticed thatas being a exothermic process, there were changes in the melting points of the samples as compared to the melting point of the drug active principle. This change indicates the existence of the polymorphism for the drug, confirming and identifying the same as morphological. |
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